Improved visualization of carcinoid liver metastases by indium-111 pentetreotide scintigraphy following treatment with cold somatostatin analogue
Identifieur interne : 000267 ( Main/Exploration ); précédent : 000266; suivant : 000268Improved visualization of carcinoid liver metastases by indium-111 pentetreotide scintigraphy following treatment with cold somatostatin analogue
Auteurs : RBID : ISTEX:259_1993_Article_BF00209003.pdfEnglish descriptors
Abstract
Five patients with hepatic metastases of midgut carcinoid underwent somatostatin receptor scintigraphy with indium-111 pentetreotide before and during treatment with octreotide. Octreotide treatment changed the biodistribution of 111In-pentetreotide significantly. Whereas the radioactivity in liver, spleen and kidney decreased, hepatic metastases showed increased contrast. In one patient, liver metastases could only be detected during octreotide treatment. These data suggest that the diagnostic reliability of somatostatin receptor scintigraphy in carcinoid liver metastases is not necessarily compromised by octreotide therapy. Because of different biodistributions, the detection of liver metastases may even be improved during octreotide therapy.
DOI: 10.1007/BF00209003
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Octreotide treatment changed the biodistribution of 111In-pentetreotide significantly. Whereas the radioactivity in liver, spleen and kidney decreased, hepatic metastases showed increased contrast. In one patient, liver metastases could only be detected during octreotide treatment. These data suggest that the diagnostic reliability of somatostatin receptor scintigraphy in carcinoid liver metastases is not necessarily compromised by octreotide therapy. Because of different biodistributions, the detection of liver metastases may even be improved during octreotide therapy.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="3288d716b000b075391dfb990cca53e42ef4f82e"><titleInfo lang="eng"><title>Improved visualization of carcinoid liver metastases by indium-111 pentetreotide scintigraphy following treatment with cold somatostatin analogue</title></titleInfo><name type="personal"><namePart type="given">Ulrich</namePart><namePart type="family">Dörr</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, Katharinenhospital, Kriegsbergstrasse 60, W-7000, Stuttgart, Germany</affiliation></name><name type="personal"><namePart type="given">Ulrich</namePart><namePart type="family">Räth</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Internal Medicine, Gastroenterology, University of Heidelberg, W-6900, Heidelberg, Germany</affiliation></name><name type="personal"><namePart type="given">Marie-Luise</namePart><namePart type="family">Sautter-Bihl</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Radiooncology and Nuclear Medicine, Städtisches Klinikum, Karlsruhe, Germany</affiliation></name><name type="personal"><namePart type="given">Gilda</namePart><namePart type="family">Guzman</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, Katharinenhospital, Kriegsbergstrasse 60, W-7000, Stuttgart, Germany</affiliation><affiliation>Departamento de Medecina Nuclear, Instituto de Neurocirurgia Investigactiones Cerebrales, DR ASENJO, Santiago, Chile</affiliation></name><name type="personal"><namePart type="given">Guzman</namePart><namePart type="family">Bach</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, Katharinenhospital, Kriegsbergstrasse 60, W-7000, Stuttgart, Germany</affiliation></name><name type="personal"><namePart type="given">Hans-Jürgen</namePart><namePart type="family">Adrian</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, Katharinenhospital, Kriegsbergstrasse 60, W-7000, Stuttgart, Germany</affiliation></name><name type="personal"><namePart type="given">Heiner</namePart><namePart type="family">Bihl</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, Katharinenhospital, Kriegsbergstrasse 60, W-7000, Stuttgart, Germany</affiliation></name><typeOfResource>text</typeOfResource><genre>Short Communication</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1993-01-23</dateCreated><dateValid encoding="w3cdtf">2004-07-16</dateValid><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">Five patients with hepatic metastases of midgut carcinoid underwent somatostatin receptor scintigraphy with indium-111 pentetreotide before and during treatment with octreotide. Octreotide treatment changed the biodistribution of 111In-pentetreotide significantly. Whereas the radioactivity in liver, spleen and kidney decreased, hepatic metastases showed increased contrast. In one patient, liver metastases could only be detected during octreotide treatment. These data suggest that the diagnostic reliability of somatostatin receptor scintigraphy in carcinoid liver metastases is not necessarily compromised by octreotide therapy. Because of different biodistributions, the detection of liver metastases may even be improved during octreotide therapy.</abstract><subject lang="eng"><genre>Key words</genre><topic>Somatostatin receptor scintigraphy</topic><topic>Carcinoid</topic><topic>Octreotide</topic><topic>Indium-111 pentetreotide</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1993</partNumber><partNumber>Volume: 20</partNumber><partNumber>Number: 5</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1993-05-01</dateIssued><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 18</identifier><recordInfo><recordOrigin>Springer-Verlag, 1993</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00209003</identifier><identifier type="matrixNumber">Art11</identifier><identifier type="local">BF00209003</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>431</start><end>433</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1993</recordOrigin><recordIdentifier>259_1993_Article_BF00209003.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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